Oxidized low-density lipoprotein receptor 1 is a protein that in humans is encoded by the OLR1 gene.
This gene encodes a receptor protein which belongs to the C-type lectin superfamily.
This gene is regulated through the cyclic AMP signaling pathway.
The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein.
This protein may be involved in the regulation of Fas-induced apoptosis.
This protein may play a role as a scavenger receptor.
Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease.
Alternative transcript variants have been described but their full-length sequence has not been determined.
Berberine inhibits ORL1 (LOX-1)with the improvement in hemoglobin A1c and AGEs in diabetics.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes mouse LOX1
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Mo
Immunogen：Recombinant protein corresponding to Arg60-Pro312 of mouse LOX1 fused to His-Tag and T7-tag at N-terminal expressed in E. coli.
