84-4425-59　LFA1a (Lymphocyte Function Associated Antigen 1 Alpha, CD11a, ITG-AL, LFA-1, LFA1-A, ITGAL, Integrin, Alpha L, CD11 antigen-like family member A, Leukocyte function-associated molecule 1 alpha chain) 200ul　363955

特徴

• Integrin, alpha Lis a human gene which functions in the immune system.
• It is involved in cellular adhesion and costimulatory signaling.
• It is the target of the drug efalizumab.
• ITGAL encodes the integrin alpha L chain.
• Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.
• This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes.
• LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3, and also functions in lymphocyte costimulatory signaling.CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- LRL MSSASLAVEW TLRNLGEDAY WVRLDLDFPR GLSFRKVEML QPHSQIPVSC EELTEESSLL TKTLKCNVSS PIFKAGKQMT LQVMFNTLLN SSWGDFVELN GTVHCENENS SLGKDNSATT RIPVLYPVNI LTEDQENSTL YISFTPKGPK TQQVQHIYKV RIQPSAYDHN MPALEALVEV PQPHSEGPIA HTWTVHTDPL VTCHCEDLKK PTRE
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.