LPS-binding protein (LBP) is serum factor known to regulate the endotoxin-induced cellular immune response.
Sepsis is a morbid condition induced by a toxin, the introduction or accumulation of which is most commonly caused by infection or trauma.
Sepsis-inducing toxins have been found associated with pathogenic bacteria, viruses, plants and venoms
Among the well described bacterial toxins are the endotoxins or lipopolysaccharides (LPS) of the gram-negative bacteria.
Upon introduction of LPS into the blood it binds to lipopolysaccharide binding protein (LBP).
LBP recognizes the lipid A region of LPS and forms high affinity complexes with both rough and smooth form LPS.
During the acute phase, LBP is synthesized by hepatocytes, and reaches very high concentrations in serum
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：porcine
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes porcine LBP.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Po
Immunogen：Recombinant protein corresponding to Asn36-Thr474 of porcine LBP fused to His-Tag and T7-tag at N-terminal expressed in E. coli.
