84-4425-22　LAT2 (Linker For Activation Of T-Cells Family, Member 2, WBSCR15, WBSCR5, WSCR5, HSPC046, LAB, NTAL, Williams-Beuren Syndrome Chromosome Region 5, Linker For Activation Of B Cells, Non-T Cell Activation Linker) 200ul　363918

特徴

• LAT2 is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder.
• This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.
• Sequence analysis predicted that human WBSCR5 is a 243aa nuclear protein, only 48% identical to the mouse sequence, that contains no known motifs.
• Northern blot analysis detected strong expression of a 1.9kb transcript in peripheral blood leukocytes, placenta, and lung, with lower expression in spleen, heart, brain, liver, and pancreas.NTAL associated with GRB2, SOS1, and GAB1 after B-cell receptor activation.
• Phosphorylation of NTAL was strongest in the presence of LCK, ZAP70, SYK, or LYN.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.