84-4425-11　［受注停止］LAMC2 (Laminin Gamma 2, B2T, EBR2, EBR2A, LAMB2T, LAMNB2, Kalinin/nicein/epiligrin 100kD subunit, Cell-scattering factor 140kD subunit, Ladsin 140kD, Large adhesive scatter factor 140kD) 200ul　363907

特徴

• LAMC2 is the gamma chain isoform laminin, gamma 2.
• The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter.
• It is expressed in several fetal tissues but differently from gamma 1 and is specifically localized to epithelial cells in skin, lung and kidney.
• The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5, which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane.
• The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- CDC NGKSRQCIFD RELHRQTGNG FRCLNCNDNT DGIHCEKCKN GFYRHRERDR CLPCNCNSKG SLSARCDNSG RCSCKPGVTG ARCDRCLPGF HMLTDAGCTQ DQRLLDSKCD CDPAGIAGPC DAGRCVCKPA VTGERCDRCR SGYYNLDGGN PEGCTQCFCY GHSASC
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.