84-4424-42　KISS1 (Kisspeptin 1, Metastin, KiSS-1 Metastasis- Suppressor) 200ul　363839

特徴

• Kisspeptin is a G-protein coupled receptor ligand for GPR54.
• Kiss1 was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis.
• It is recently become clear that kisspeptin-GPR54 signaling has an important role in initiating GnRH secretion at puberty, the extent of which is an area of ongoing research.Kisspeptin is a metastasis suppressor of melanomas and breast cancers without affecting tumorigenicity.
• The encoded protein may function to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas.
• Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization.
• A polymorphism in the terminal exon of this mRNA results in two protein isoforms.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• AA Sequence:MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-MISMASWQLL LLLCVATYGE PLAKVKPGST GQQSGPQELV NAWEKESRYA ESKPGSAGLR ARRSSPCPPV EGPAGRQRPL CASRSRLIPA PRGAVLVQRE KDLSTYNWNS FGLRYGRRQA ARAARG
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.