Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors.
Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities.
Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth.
This gene encodes theITGB4) subunit, a receptor for the laminins.
This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma
Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes mouse ITGb4.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Mo
Immunogen：Recombinant protein corresponding to Ser1098-Leu1356 of mouse ITGb4 fused to His-Tag and T7-tag at N-terminal expressed in E. coli.
