It makes up half of the alpha2 beta1 integrin duplex.
Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain.
They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets.
Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
Kunicki et al.
(1997) identified 2 silent, linked polymorphisms, 807C-T and 873G-A, within the coding region of the ITGA2 gene that are associated with GP Ia/IIa surface expression, i.e., the number of GP Ia/IIa copies on the platelet membrane.
High surface expression was found in platelets derived from 807T homozygotes, whereas low surface expression was found in platelets from 807C homozygotes.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human ITGa2.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Lys678-Asn894 of human ITGa2 fused to His-Tag and T7-tag at N-terminal expressed in E. coli.
