INSL3 encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females.
Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility.
It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent.
The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism.
Expressed in prenatal and postnatal Leydig cells.
Found as well in the corpus luteum, trophoblast, fetal membranes and breast.
Seems to play a role in testicular function.
May be a trophic hormone with a role in testicular descent in fetal life.
Is a ligand for LGR8 receptor.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 0.5-2ug/ml Immunohistochemistry (Paraffin): 5-20ug/ml Immunocytochemistry: 5-20ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes rat INSL3.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Rt
Immunogen：Recombinant protein corresponding to Gln63-His129 of rat INSL3 fused to His-Tag and GST-tag at N-terminal expressed in E. coli.
