84-4423-03　IL31 (Interleukin 31) 200ul　363701

特徴

• Interleukin-31 (IL-31) is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2).
• The structure of IL-31 places it in the IL-6 family of cytokines.
• IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor subunits.
• These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells.
• IL-31 is believed to play a role in inflammation of the skin.
• IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA and OSMR that is constitutively expressed on epithelial cells and keratinocytes.
• IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100ELISA: 1:100-1:5000Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- SFG APISKEDLRT TIDLLKQESQ DLYNNYSIKQ ASGMSADESI QLPCFSLDRE ALTNISVIIA HLEKVKVLSE NTVDTSWVIR WLTNISCFNP LNLNISVPGN TDESYDCKVF VLTVLKQFSN CMAE
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.