Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of cytokines.
IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells.
IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin.
In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells.
The 176aa IL20 protein contains 6 conserved cysteine residues and shares 76%aa identity with its murine counterpart.
Based on amino acid identities, IL20 is most homologous to 3 members of the IL10 family, IL19, MDA7, and IL10.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Optimal dilutions to be determined by the researcher.