Interleukin-17 receptor C is a single-pass transmembrane protein that shares limited similarity with the interleukin-17 receptor.
Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only three have been determined to date.
The predicted full-length 720aa protein has an N-terminal signal peptide, followed by an acidic extracellular domain with 9 potential N-glycosylation sites, a single-pass transmembrane domain, and a basic cytoplasmic region with multiple phosphorylation sites.
It has a calculated molecular mass of 76.4kD and shares 22%aa identity with IL17R.strongest expression in prostate, kidney, liver, heart, and muscle, with barely detectable levels in thymus and peripheral blood leukocytes.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human IL17RC.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Asn257-Asn477 of human IL17RC, fused to His-Tag and T7-tag at N-terminal expressed in E. coli.
