Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes.
It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils.
The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A.
Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.
IL17 induces nuclear factor kappa-B (NFKB) and the expression of IL6, intercellular adhesion molecule-1 (ICAM1), granulocyte macrophage colony-stimulating factor, and prostaglandin E2, as well as the maturation of CD34-positive hematopoietic precursors into neutrophils.
IL17R is a receptor for IL17.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes rat IL17RA.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Rt
Immunogen：Recombinant protein corresponding to Gly617-Gly847 of rat IL17RA, fused to His-Tag and T7-tag at N-terminal expressed in E. coli.
