84-4419-69　GRN (Granulin, GEP, GP88, PCDGF, PEPI, PGRN, Proepithelin, Acrogranin, Glycoprotein of 88Kd, Paragranulin) 200ul　363370

特徴

• Granulin is a protein encoded by the GRN gene.Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif.
• The 88kD precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor.
• Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6kD peptides.
• These smaller cleavage products are named granulin A, granulin B, granulin C, etc.
• Epithelins 1 and 2 are synonymous with granulins A and B, respectively.
• Both the peptides and intact granulin protein regulate cell growth.
• However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- CLDQGGANYS CCNPLLDTWP RITSHHLDGS CQTHGHCPAG YSCLLTVSGT SSCCPFSKGV SCGDGYHCCP QGFHCSADGK SCFQMSDNPL GAVQCPGSQF ECPDSATCCI MVDGSWGCCP MPQASCCEDR VHCCPHGASC DLVHTRCVSP TGTHTLLKKF PAQKTNRAVS LPFSVVCPDA KTQCPDDSTC CELPTGKYGC CPMPNAICCS DHLHCCPQDT VCDLIQSKCL SKNYTTDLL
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.