Geranylgeranyl pyrophosphate synthetase is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity.
The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate.
GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor.
Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
The deduced protein shows 16% identity with farnesyl diphosphate synthase and contains 3 N-glycosylation sites as well as the 5 domains common to trans-prenyltransferases.
expression in heart, skeletal muscle, and testis and the shorter transcript as the major species in these tissues.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human GGPS1.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Met1-His290 of human GGPS1, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
