84-4418-55　GDF3 (Growth Differentiation Facotr 3, Vgr2, Vg-Related Gene 2) 200ul　363257

特徴

• Growth differentiation factor-3 (GDF3) is protein belonging to the transforming growth factor beta (TGF-Beta) superfamily.
• It has high similarity to other TGF-Beta superfamily members called Vg1 (found in frogs), BMP2, BMP6 and GDF1, but lacks one of the conserved cysteine residues common to all other TGF-Beta superfamily members.Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults
• GDF3 is a bi-functional protein that inhibits some TGF-Beta superfamily members (e.g.
• BMPs) while activating others, thus regulating the balance between different modes of TGF-beta signaling.
• It has been shown to negatively and positively control differentiation of embryonic stem cells in mice and humans.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- AAISVPKG FCRNFCHRHQ LFINFQDLGW HKWVIAPKGF MANYCHGECP FSMTTYLNSS NYAFMQALMH MADPKVPKAV CVPTKLSPIS MLYQDSDKNV ILRHYEDMVV DECGCG
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.