84-4418-52　GDF2 (Growth Differemtiation Factor 2, BMP9, Bone Morphogenetic Protein 9) 200ul　363254

特徴

• Growth differentiation factor 2 (GDF2) is a protein also known as bone morphogenetic protein (BMP)-9 that belongs to the transforming growth factor beta superfamily.
• It has a role in inducing and maintaining the ability of embryonic basal forebrain cholinergic neurons (BFCN) to respond to a neurotransmitter called acetylcholine; BFCN are important for the processes of learning, memory and attention.
• GDF2 is also important for the maturation of BFCN
• Another role of GDF2 has been recently suggested.
• GDF2 is a potent inducer of hepcidin in liver cells (hepatocytes) and can regulate iron metabolism.
• The physiological receptor of GDF2 is thought to be activin receptor-like kinase 1, ALK1 (also called ACVRL1), an endothelial-specific type I receptor of the TGF-beta receptor family.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGHHHHHHSGSEF- QKPLQNWEQ ASPGENAHSS LGLSGAGEEG VFDLQMFLEN MKVDFLRSLN LSGIPSQDKT RAEPPQYMID LYNRYTTDKS STPASNIVRS FSVEDAISTA ATEDFPFQKH ILIFNISIPR HEQITRAELR LYVSCQNDVD STHGLEGSMV VYDVLEDS
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.