84-4417-77　FXR (Farnesoid X Receptor, NR1H4, BAR, FXR, HRR1, RIP14, Nuclear Receptor Subfamily 1, Group H, Member 4, Bile acid receptor, Farnesol receptor HRR-1, Retinoid X receptor-interacting protein 14) 200ul　363179

特徴

• The farnesoid X receptor (FXR),is a nuclear hormone receptor with activity similar to that seen in other steroid receptors such as estrogen or progesterone but more similar in form to PPAR, LXR and RXR.
• FXR is encoded by the NR1H4 gene.
• FXR is expressed at high levels in the liver and intestine.
• Chenodeoxycholic acid and other bile acids are natural ligands for FXR.
• Like other steroid receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA which elicits expression or transrepression of gene products.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap