FMR1 is normally made in many tissues, especially in the brain and testes.
It may play a role in the development of synaptic connections between nerve cells in the brain, where cell-to-cell communication occurs.
The connections between nerve cells can change and adapt over time in response to experience (a characteristic called synaptic plasticity).
FMRP may help regulate synaptic plasticity, which is important for learning and memory
One region of the FMR1 gene contains a 3 base Variable Number Tandem Repeat (VNTR, or more specifically, a trinucleotide repeat).
The sequence CGG is repeated a number of times.
In most healthy individuals, the number of CGG repeats ranges from fewer than 10 to about 40, with the median at about 29 repeats.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human FMR1.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Met1-Val314 to human FMR1, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
