84-4417-18　FKBP1A (FK506 Binding Protein 1A, FKBP-12, FKBP1, FKBP12C, PKC12, PKCI2, Calstabin-1, Rotamase, 12 kDa FK506-binding protein, Peptidyl-prolyl cis-trans isomerase FKBP1A, Immunophilin FKBP12) 200ul　363120

特徴

• FKBP1A is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking.
• This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin.
• It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor.
• It also interacts with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor.
• In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
• There is evidence of multiple alternatively spliced transcript variants for this gene, but the full length nature of some variants has not been determined.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGHHHHHHSGSEF-GVEIETISP GDGRTFPKKG QTCVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF EEGAAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF DVELLNLE
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.