FGF19is a member of the fibroblast growth factor family.
FGF19 was detected only in fetal but not adult brain tissue.
FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption.
Bile acids bind to the farnesoid X receptor, stimulating FGF19 transcription.
Several FXR / bile acid response elements have been identified in the FGF19 gene.
Human FGF19 transcripts have been shown to be stimulated approximately 300-fold by physiological concentrations of bile acids including chenodeoxycholic acid, glycochenodeoxycholic acid and obeticholic acid in explants of ileal mucosa.FGF19 regulates new bile acid synthesis, acting through the FGFR4/Klotho-Beta receptor complexes in the liver to inhibit CYP7A1.
FGF19 has metabolic effects, affecting glucose and lipid metabolism when used in experimental mouse models.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human FGF19.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Gly4-Lys216 of human FGF19, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
