84-4416-18　F13B (Coagulation Factor XIII B Polypeptide, F13-B, FXIIIB, Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain) 200ul　363021

特徴

• Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade.
• Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits.
• The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules.
• Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin.
• Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII.
• This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.5-2ug/mlImmunocytochemistry: 5-20ug/mlImmunohistochemistry: 5-20ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.