84-4416-16　F13A1 (Coagulation Factor XIII A1 Polypeptide, F13-A1, FXIIIA1, Protein-glutamine gamma-glutamyltransferase A chain, Transglutaminase A chain, Coagulation factor XIII A chain) 200ul　363019

特徴

• Coagulation factor XIII A subunit.
• Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade.
• Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits.
• The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules.
• Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin.
• Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII.
• This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100ELISA: 1:100-1:5000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.