Dynamins represent one of the subfamilies of GTP-binding proteins.
These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain.
Dynamins are associated with microtubules.
They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts.
Dynamins bind many proteins that bind actin and other cytoskeletal proteins.
Dynamins can also self-assemble, a process that stimulates GTPase activity.
Four alternatively spliced transcripts encoding different proteins have been described.
Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human DNM2.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Leu533-Glu731 of human DNM2, fused to His-Tag and T7-tag at N-terminal expressed in E. coli.
