84-4414-45　DKC (Dyskerin, DKC1, NAP57, NOLA4, NAP57, Dyskeratosis Congenita 1, H/ACA Ribonucleoprotein Complex Subunit 4, Nopp140-associated protein of 57kD, Nucleolar protein family A member 4) 200ul　362850

特徴

• Dyskeratosis congenita 1, dyskerin, is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins).
• The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins.
• The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus.
• Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted.
• The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins.
• The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein (MPP1) gene and is transcribed in a telomere to centromere direction.
• Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.