Cathepsin K is a lysosomal cysteine protease involved in bone remodeling and resorption.
This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts.
Cathepsin K is a protease, which is defined by its high specificity for kinins, that is involved in bone resorption.
The enzyme's ability to catabolize elastin, collagen, and gelatin allow it to break down bone and cartilage.
This catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema.
Cathepsin K inhibitors, such as odanacatib, show great potential in the treatment of osteoporosis.
Cathepsin K expression is stimulated by inflammatory cytokines that are released after tissue injury.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：bovine
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes bovine CTSK.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Bo
Immunogen：Recombinant protein corresponding to bovine CTSK expressed in E. coli.
