CTBP2 produces alternative transcripts encoding two distinct proteins.
One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons.
Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases.
A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely.
Blast analysis shows that this gene is present on chromosome 10.
Interacts with the C-terminus of adenovirus E1A protein.
Can form homodimers or heterodimers of CTBP1 and CTBP2.
Interacts with HIPK2 and ZNF217.
Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression By similarity.
Interacts with PNN, NRIP1 and WIZ
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human CTBP2.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Met1-Leu252 of human CTBP2, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
