The most prominent clinical syndrome associated with a disordered hypersecretion of Calcitonin is medullary carcinoma of the thyroid (MTC).
MTC is a tumor of the Calcitonin producing C-cells of the thyroid gland.
Although MTC is rare, comprising 5-10% of all thyroid cancer, it is often fatal.
It may occur sporadically or in a familial form that is transmitted as an autosomal dominant trait.
MTC has great clinical importance because of its familial distribution.
Further, it leant itself to be diagnosed early by serum Calcitonin and total cure for early sub-clinical disease is possible1.
This is frequently associated with other clinical features and it has good potential for cure with surgery.
Although a rare tumor, it can occur in a familial pattern1 as a Type II multiple endocrine neoplasia.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：canine
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes canine CT.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Ca
Immunogen：Recombinant protein corresponding to Ala26-Arg130 of canine Calcitonin, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
