84-4412-65　CR2 (Complement Receptor 2, CD21, C3DR, Complement Component (3d/Epstein Barr Virus) Receptor 2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor) 200ul　362672

特徴

• CR2 and CD21, is a protein involved in the complement system.
• It binds to iC3b (inactive derivative of C3b), C3dg, or C3d.
• B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation.CR2 on mature B cells form a complex with two other membrane proteins, CD19 and CD81(=TAPA-1).
• The CR2-CD19-CD81 complex is often called the B cell coreceptor complex, because CR2 binds to antigens through attached C3d (or iC3b or C3dg) when the menbrane IgM binds to the antigen.
• This results in the B cell to have greatly enhanced response to the antigen.
• Epstein-Barr virus (EBV) binds to B cells at CR2 during infection of these cells.
• Yefenof et al.
• (1976) found complete overlapping of EBV receptors and C3 receptors on human B lymphocytes.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000Western Blot: 1:50-400Immunocytochemistry: 1:50-500Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Optimal dilutions to be determined by the researcher.
• AA Sequence:MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-KH TGMMAENFLY GNEVSYECDQ GFYLLGEKKL QCRSDSKGHG SWSGPSPQCL RSPPVTRCPN PEVKHGYKLN KTHSAYSHND IVYVDCNPGF IMNGSRVIRC HTDNTWVPGV PTCIKKAFIG CPPPPKTPNG NHTGGNIARF SPGMSILYSC DQGYLLVGEA LLLCTHEGTW SQPAPHCKEV NCSSPADMDG IQKGLEPRKM YQYGAVVTLE CEDGYMLEGS PQSQCQS
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.