84-4412-17　COL10 (Collagen Type X, COL10A1, COL10-A1, Schmid Metaphyseal Chondrodysplasia, Collagen Alpha-1(X)chain) 200ul　362624

特徴

• Collagen alpha-1(X) chain is the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification.
• Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer.
• Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).
• During development and growth of long bones, chondrocytes pass sequentially through a proliferative, a hypertrophic and a degenerative stage, each characterized by a particular set of collagen types.
• Proliferative (stage I) chondrocytes synthesize type II collagen as the major collagen and types IX and XI as the minor collagens.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- AFTV ILSKAYPAIG TPIPFDKILY NKQQHYDPRT GIFTCKIPGI YYFSYHIHVK GTHAWVGLYK NGTPVMYTYD EYIKGYLDQA SGSAVIDLTE NDQVWLQLPN AGSNGLYSPE YVHSSFSGFL VAPM
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.