Loss of genetic material at the cytogenetic level and loss of heterozygosity (LOH) are frequently observed in tumors.
The 11q22-q24 region has deletions or LOH in a variety of tumor types.
Replacement of the missing copy of chromosome 11 in the A549 adenocarcinoma cell line with a normal chromosome 11 reversed tumorigenicity in nude mice, suggesting the existence of a tumor suppressor gene.
TSLC1 localized in perinuclear and plasma membranes.
The predicted 442aa protein contains a signal peptide and a transmembrane domain.
IGSF4 shares 65% identity with neural cell adhesion molecule-1 (NCAM1) and NCAM2 within their Ig-like C2-type domains.
Northern blot analysis revealed expression of a 4.4kb transcript in all tissues tested except leukocytes.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human CADM1.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Ala2-Phe22 of human CADM1 fused to His-Tag and GST-tag at N-terminal expressed in E. coli
