Complement component 1S is a protein involved in the complement system.
C1s cleaves C4, which eventually leads to the production of the C4b-C2a form of C3-convertase.MacKinnon et al.
(1987) derived the complete aa sequence of C1s from molecular cloning of cDNA.
Tosi et al.
(1987) presented the complete cDNA sequence of C1s.
Kusumoto et al.
(1988) found that the aa sequence of C1s was 40.5% identical to that of C1r, with excellent matches of tentative disulfide bond locations conserving the overall domain structure of C1r.
In a 27-month-old girl with multiple autoimmune diseases, Dragon-Durey et al.
(2001) detected selective C1S deficiency resulting from a nonsense mutation in exon 12 of the C1S gene.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-5000Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human Complement component 1S.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to Ile438-Pro685 of human Complement component 1S fused to His-Tag and T7-tag at N-terminal expressed in E. coli.
