84-4409-06　BPI (Bactericidal/Permeability Increasing Protein, CAP 57) 200ul　362315

特徴

• BPI was initially identified in neutrophils, but is found in other tissues including the epithelial lining of mucus membranes.
• It is an endogenous antibiotic protein with potent killing activity against some bacteria (Gram-negative bacteria).
• It binds to compounds called lipopolysaccharides produced by Gram-negative bacteria.
• Lipolysaccharides are potent activators of the immune system, however BPI at certain concentrations can prevent this activation
• Because lipopolysaccharides are potent inflammatory agents, and the action of antibiotics can result in the release of these compounds, the binding capacity of BPI was explored as a possible means of reducing injury.
• Xoma Ltd.
• developed a recombinant 25kD portion of the BPI molecule called rBPI21, NEUPREX or opebecan.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LF Q GPLGSEF- S KFRLTTKFFG TFLPEVAKKF PNMKIQIHVS ASTPPHLSVQ PTGLTFYPAV DVQAFAVLPN SSLASLFLIG MHTTGSMEVS AESNRLVGEL KLDRLLLELKHSNIGPFPVE LLQDIMNYIV PILVLPRVNEKLQKGF
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.