The protein encoded by this gene is a member of the TGF-Beta superfamily.
Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage.
It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer.
BMP7 may be involved in bone homeostasis.
It is expressed in the brain, kidneys and bladder.
BMP7 has been discovered to be crucial in the determination of ventral-dorsal organization in zebrafish.
BMP7 causes the expression of ventral phenotypes while its complete inhibition creates a dorsal phenotype.
Moreover, BMP7 is eventually partially "turned off" in embryonic development in order to create the dorsal parts of the organism.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：bovine
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes bovine BMP7.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Bo
Immunogen：Recombinant protein corresponding to Asp123-Lys393 from bovine BMP7 fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
