Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-Beta superfamily of proteins.
BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage.
It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction.
It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition.
BMP-2 and BMP-7 are osteogenic BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types.
Bone morphogenetic protein 2 is shown to stimulate the production of bone and recombinant human protein (rhBMP-2) and is currently available for orthopaedic usage in the United States.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.