B-cell lymphoma 3-encoded protein is a proto-oncogene candidate.
It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia.
The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins
This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers.
The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.Wulczyn et al.
(1992) and Franzoso et al.
(1992) found that the BCL3 gene encodes an inhibitor (antagonist) for subunit 2 of nuclear factor kappa-B (NFKB2).
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
