Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity.
Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia.
The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical.
Butyrylcholinesterase is believed to play a role in the body's ability to metabolize the drug cocaine.
In 2008, an experimental new drug was discovered for the potential treatment of cocaine abuse and overdose based on the BChE structure.
It was shown to remove cocaine from the body 2000 times as fast as the natural form of BChE.
Studies in rats have shown that the drug prevented convulsions and death when administered cocaine overdoses.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes rat BCHE.
Isotype：IgG
Calc Applications Abbrev：E IC IHC WB
Calc Crossreactivity：Rt
Immunogen：Recombinant protein corresponding to Asn345-Phe570 of rat BCHE, fused to two N-terminal Tags, His-Tag and T7-tag, expressed in E. coli.
