84-4408-25　ATXN1 (Ataxin 1, ATX1, SCA1, AXH Domain, Spinocerebellar Ataxia 1, Olivopontocerebellar Ataxia 1, Autosomal Dominant, Ataxin 1) 200ul　362235

特徴

• The protein ataxin-1 is encoded by the ATXN1 gene, which is mutated to contain an expanded CAG trinucleotide repeat in spinocerebellar ataxia-1 (SCA1), an autosomal dominant form of olivopontocerebellar atrophy.
• Although there are forms of spinocerebellar ataxia that are indistinguishable clinically from SCA1, e.g., SCA2, the designation SCA1 is used for the form that maps to 6p
• Banfi et al.
• (1994) demonstrated that the ATXN1 gene encodes an 816aa protein with a molecular mass of 87kD.
• The (CAG)n repeat, coding for a polyglutamine tract, lies within the coding region, and the protein is transcribed from both the wildtype and the CAG-expanded ATXN1 allele.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- PYESRHVVVH PSPADYSSRD TSGVRGSVMV LPNSSTPSAD LEAQQTTHRE ASPSTLNDKS GLHLGKPGHR SYALSPHTVI QTTHSASEPL PVGLPATAFY AGTQPPVIGY LSGQQQAITY AGGLPQHLVI PGNQPLLIPV GSPDMDTPGA ASAIVTSSPQ FAAVPHTFVT TALPKSENFN PEALVTQAAY PAMVQAQIHL PVVQSVASPT TASPTLPPYF MKGSIIQLAN GELKKVEDLK TEDFIQSAEI SNDLKID
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.