84-4407-48　APOE (AApolipoprotein E, Apo-E, AD2, Apoprotein, Alzheimer Disease 2, E4-Associated,Late Onset) 200ul　362159

特徴

• Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells.
• ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents.
• Apolipoprotein E has many functions in the body.
• When it is synthesized by the liver as part of VLDL it functions in the transport of triglycerides to the liver tissue.
• It is also incorporated into HDL (as HDL-E) and functions in cholesterol distribution among cells.
• It is also incorporated into intestinally synthesized cholymicrons and transports dietary triglycerides and cholesterol.
• It is involved in lipid metabolism by mediating the receptor binding of apo-E lipoproteins to the LDL receptor.
• Receptor binding begins the cellular uptake of lipoproteins to be used in intracellular cholesterol metabolism.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:5000 Western Blot: 1:50-400Immunohistochemistry (frozen): 1:50-500Immunohistochemistry (paraffin): 1:10-100Immunocytochemistry: 1:50-500Optimal dilutions to be determined by the researcher.
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- KV EQAVETEPEP ELRQQTEWQS GQRWELALGR FWDYLRWVQT LSEQVQEELL SSQVTQELRA LMDETMKELK AYKSELEEQL TPVAEETRAR LSKELQAAQA RLGADMEDVC GRLVQYRGEV QAMLGQSTEE LRVRLASHLR KLRKRLLRDA DDLQKRLAVY Q
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.