84-4404-45　［取扱停止］ZBED1 (Zinc Finger BED Domain-containing Protein 1, Putative Ac-like Transposable Element dREF Homolog, ALTE, DREF, KIAA0785, TRAMP) 50ul　361467

特徴

• ZBED1 (zinc finger BED domain-containing protein 1), also known as ALTE (Ac-like transposable element), DREF or TRAMP, is a 694aa protein that localizes specifically to granular structures within the nucleus.
• Expressed ubiquitously at low levels and present at higher levels in heart, placenta, spleen and skeletal muscle, ZBED1 is thought to function as a transcription factor that regulates a number of ribosomal protein (RP) encoding genes, thereby playing a role in the cell cycle and in cell proliferation events.
• ZBED1 contains one BED-type zinc finger and binds specifically to 5'-TGTCG[CT]GA[CT]A-3' DNA regions found in RP promotors.
• Additionally, ZBED1 binds strongly to the promotor region of Histone H1 (a protein required for the condensation of nucleosomes into higher order structures), subsequently activating H1 transcription.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.