WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of aa40-60 that commonly form a tertiary propeller structure.
While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking.
WDR68 (WD repeat-containing protein 68), also known as DCAF7 (DDB1- and CUL4- associated factor 7), HAN11 or WDR68, is a 342aa protein that belongs to the WD repeat DCAF7 family and contains 4 WD repeats.
Localizing to the cytoplasm and nucleus, WDR68 is involved in protein modification and ubiquitination pathways, and interacts directly with Dyrk1A, Dyrk1B and Dia 1.
WDR68 is involved in craniofacial development, and may be involved in skin development.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human WRD68. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human WRD68.
