WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60aa’s, which commonly form a tertiary propeller structure.
While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms involving signal transduction, apoptosis, transcriptional regulation, cell cycle control.
WD repeats serve as sites for protein-protein interaction and some seem to mediate the assembly of protein complexes.
With 11 WD repeats, WDR1 (WD repeat domain 1), also known as AIP1 or NORI-1, is a 606aa protein that localizes to the cytoskeleton and is a member of the WD repeat AIP1 family.
Existing as two alternatively spliced isoforms, WDR1 induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human WDR1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to full length human WDR1.
