GTPase-activating proteins(GAPs) accelerate the intrinsicrate of GTP hydroysis of Ras-related proteins, resulting in downregulation of their active form.
RN-tre (related to the N-terminal of tre), also known as USP6NL (USP6 Nterminal like) or TRE2NL, is an 828aa protein that contains one RabGAP TBC domain.
Expressed in a wide variety of tissues, RN-tre functions as a GTPase- activating protein for Rab 5A and is thought to be involved in receptor trafficking, as well as in the inhibition of EGFR internalization.
In response to DNA damage, RN-tre may be phosphorylated by ATM or ATR.
The gene encoding RN-tre maps to human chromosome 10, which houses over 1200 genes and comprises nearly 4.5% of the human genome.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human USP6NL. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa446-491 of human USP6NL.
