UDP-glucuronosyltransferase isoenzymes (UGTs) catalyze the glucuronidation of small lipophilic molecules, thereby regulating the bioactivity and metabolic fate of a wide range of endogenous compounds and xenobiotics.
Glucuronidation increases the polarity of lipophilic molecules and facilitates their entry into aqueous compartments and, ultimately, their excretion.
In essence, glucuronidation provides a protective function by terminating or attenuating the biological activity of its substrates.
The UGT3A family of isoenzymes are expressed in liver and kidney, and to a lesser, in the gastrointestinal tract.
UGT3A2 (UDP glycosyltransferase 3 family, polypeptide A2) is a 523aa single-pass type I membrane protein that belongs to the UDP-glycosyltransferase family.
It has been suggested that members of the UGT3A family may have an important role in the metabolism and elimination of ursodeoxycholic acid, a metabolic byproduct of intestinal bacteria.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human UGT3A2. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Recombinant protein corresponding to UGT3A2.
