TUSC2 (tumor suppressor candidate 2), also known as FUS1, LGCC or PDAP2, is a 110aa protein that is expressed at high levels in kidney, pancreas, lung, heart and skeletal muscle where it is thought to function as a tumor suppressor.
More specifically, TUSC2 inhibits invasive colony formation by inducing G1 cell cycle arrest and ultimately causing apoptosis, thereby preventing tumor growth.
The gene encoding TUSC2 maps to human chromosome 3, which houses over 1100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.
Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B.
Applications:Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:50-1:200Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human TUSC2. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to full length human TUSC2.
