84-4402-87　［取扱停止］TSC22D3 (TSC22 Domain Family Protein 3, DSIP-immunoreactive Peptide, Protein DIP, hDIP, Delta Sleep-inducing Peptide Immunoreactor, Glucocorticoid-induced Leucine Zipper Protein, GILZ, TSC-22-like Protein, TSC-22-Related Protein, TSC-22R, DSIPI, GILZ) 50ul　361372

特徴

• Glucocorticoid-induced leucine zipper (GILZ) is a leucine zipper protein ex-pressed in normal lymphocytes from thymus, spleen and lymph nodes.
• It is absent in nonlymphoid tissues including brain, liver and kidney.
• GILZ mediates the immunosuppressive effects of glucocorticoid hormones; its expression is induced in T cells by dexamethasone.
• GILZ protects T cells from an anti-CD3 antibody-induced apoptosis by inhibiting Fas and Fas ligand expression.
• It interferes with Egr-2, Egr-3, NFAT/AP-1-inducible transcription factors and AP-1.
• The interaction of GILZ with c-Fos and c-Jun inhibits the binding of active AP-1 to its DNA consensus site in vitro.
• GILZ also binds NFkB subunits and inhibits the NFkB nuclear translocation.
• It inhibits T cell receptor-induced interleukin-2/interleukin-2 receptor expression.
• The binding of GILZ to Raf-1 prevents Raf-MEK-ERK activation in the MAPK pathway.
• GILZ is expressed by normal macrophages in nonlymphoid tissues and by tumor-infiltrating macrophages in Burkitt lymphomas.
• The gene encoding human GILZ maps to chromosome Xq22.3.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.