84-4402-57　［取扱停止］TRAF3IP1 (TRAF3-Interacting Protein 1, Interleukin-13 Receptor alpha 1-binding Protein 1, Intraflagellar Transport Protein 54 Homolog, Microtubule-Interacting Protein Associated with TRAF3, MIP-T3, IFT54, MIPT3) 50ul　361354

特徴

• Tumor necrosis factor receptor (TNFR) superfamily members transmit signals regulating proliferation, differentiation and apoptosis in various types of cells.
• TNFR-associated factors (TRAFs) are a family of proteins that were initially discovered as downstream signal transducers of the TNFR superfamily.
• TRAF3 contains an N-terminal ring finger/zinc finger region that is thought to be essential for downstream signaling.
• MIP-T3 is associated with TRAF3.
• MIP-T3 binds to taxol-stabilized microtubules and to tubulin in vitro, and MIP-T3 recruits TRAF3 to microtubules when both proteins are overexpressed.
• The MIP-T3/TRAF3 interaction requires the coiled-coil TRAF-N domain of TRAF3.
• This interaction may provide a novel mechanism in sequestering TRAF3 to the cytoskeletal network.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.