84-4402-50　［取扱停止］TP53INP2 (Tumor Protein p53-inducible Nuclear Protein 2, Diabetes and Obesity-regulated Gene, p53-inducible Protein U, PIG-U, TP53INP2) 100ul　361350

特徴

• TP53INP2 (tumor protein p53 inducible nuclear protein 2), also known as DOR or PINH, is a 220aa nuclear protein that is expressed in developing murine brain and spinal cord, as well as in the sensory and motor neuron tracts of the peripheral nervous system.
• A novel protein involved in the autophagy of mammalian cells, TP53INP2 translocates from the nucleus to the autophagosome structures after activation of autophagy by rapamycin or starvation.
• Necessary for autophagosome development and considered a scaffold protein, TP53INP2 recruits LC3 and/or LC3-related proteins, such as GABARAP and GABARAP-like2, to the autophagosome membrane by interacting with the transmembrane protein TMEM49.
• The gene encoding TP53INP2 is located on human chromosome 20, which is comprised of approximately 2% of the human genome and contains nearly 63 million bases that encode over 600 genes.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.