Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of actin filaments.
A component of the membrane skeleton, TMOD binds to the N-terminal of tropomyosin, which coats the surface of actin, and thus blocks the elongation and depolymerization of actin filaments.
Four TMOD isoforms, TMOD1-TMOD4, have been characterized in humans.
TMOD expression is isoform-specific; TMOD3 is expressed ubiquitously, whereas TMOD2 and TMOD4 are expressed in neuronal tissue and muscle, respectively.
TMOD4, which has a similar organization to TMOD2, is intergenically spliced by the putative transformation suppressor gene product YL-1.
The human TMOD4 gene maps to the telomeric end of chromosome 1q12, and encodes a 351aa protein.
The expression and chromosomal location of the TMOD4 gene make it a candidate for limb girdle musclular dystrophy 1B.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human TMOD4. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human TMOD4.
