A total of three members of the TGFB family, TGFB1, TGFB2 and TGFB3, have been identified in mammals.
Each is synthesized as a latent precursor that is subsequently cleaved forming the 112aa growth factor which becomes active upon dimerization.
TGFBs mediate their activity by high affinity binding to the type II receptor transmembrane protein with a cytoplasmic serine-threonine kinase domain.
TGFB RIII (transforming growth factor beta receptor type 3), also known as TGFBR3 or TGFR-3, is an 850aa secreted and single-pass type I membrane protein that contains one ZP domain and may assist in capturing TGFB for presentation to signaling receptors.TGFB RIII undergoes post-translational modification by glycosaminoglycan groups (GAG) and is encoded by a gene that maps to human chromosome 1p22.1.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human TGFBR3. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to residues in human TGFBR3.
